| Vabomere[^t2a] |
Beta-lactam + Beta-lactamase inhibitor |
“Combination of Meropenem and Vaborbactam” |
Melinta |
Yes[^t2b] |
| Baxdela[^t2c] |
Fluoroquinolone |
Bacterial Topoisomerase Inhibitor |
Melinta |
Yes[^t2d] |
| Xerava[^t2e] |
Halogenated-Tetracycline |
Inhibition of Bacterial Ribosomal S30 subunit |
Tetraphase |
Yes[^t2f] |
| Nuzyra[^t2g] |
Tetracycline |
Inhibition of Bacterial Ribosomal S30 subunit |
Paratek |
Yes[^t2h] |
| Sivextroi
|
Oxazolidinone |
Inhibition of Bacterial Ribosomal S50 subunit |
Cubist |
Yes[^t2j] |
| Zerbaxa[^t2k] |
Cephalosporin + Beta-Lactamase inhibitor |
Combination of Ceftolozane and Tazobactam |
Cubist |
Yesl
|
| Dalvance[^t2m] |
Lipoglycopeptide |
Interferes with peptidoglycan cross-links |
Allergan |
Yes[^t2n] |
| Oritavancin[^t2o] |
Lipoglycopeptide |
Interferes with peptidoglycan cross-links and bacterial RNA |
Melinta |
Yes[^t2p] |
| Avycaz[^t2q] |
Cephalosporin + Beta-lactamase inhibitor |
Combination of Ceftazidime and Avibactam |
Allergan |
Yes[^t2r] |
| Zemdri[^t2s] |
Aminoglycoside |
Inhibition of Bacterial Ribosomal S30 subunit |
Achaogen |
Yes[^t2t] |
| Recarbrio[^t2u] |
Carbapenem Betalactam + Renal Dehydropeptidase Inhibitor + Betalactamase inhibitor |
New combination of:
Imipenem – Old antibiotic that limits cell wall formation
Cilastatin- Limits kidneys from processing the antibiotic
Relebactam- Prevents Betalactamase from breaking down antibiotic
|
Merck |
Yes[^t2v] |
| Pretomanid[^t2w] |
Nitroimidazooxazine antibacterial |
Pretomanid blocks mycolic acid, wall formation |
TB-Alliance |
Yes[^t2x] |
| Xenleta[^t2y] |
Pleuromutilin antibacterial |
Novel* Inhibits the interactions on bacterial P and A sites of the 50S ribosomal subunit |
Nabriva Therapeutics |
Yes[^t2z] |
| Fetroja[^t2aa] |
Unique Cephalosporin |
Inhibits cell wall formation using bacterial “siderophore iron uptake mechanism” |
Shionogi |
Yes[^t2ab] |